GLPG634 analog
N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl] cyclopropanecarboxa
CAS: 1206101-20-3
Molecular Formula: C23H18N6O2
GLPG634 analog - Names and Identifiers
GLPG634 analog - Physico-chemical Properties
| Molecular Formula | C23H18N6O2 |
| Molar Mass | 410.43 |
| Storage Condition | -20°C |
| In vitro study | In cell lines, GLPG0634 inhibited JAK1/JAK3/γc signaling induced by IL-2 and IL-4 and JAK1/TYK2 type II receptor signaling induced by IFN-αB2 with an IC50 in the range of 150 to 760 nM. At the cellular level, GLPG0634 is more selective for JAK/STAT signaling comprising JAK1 than JAK2 kinase. In addition, GLPG0634 also inhibits the proliferation of Th1,Th2, and Th17 cells. |
| In vivo study | After oral administration, the absolute bioavailability was moderate in rats (45%) and higher in mice (100%). GLPG0634 (30 mg/kg per day (RAT);50 mg/kg twice a day (mouse)) dose-dependently reduces inflammation, cartilage, and bone degradation. |
GLPG634 analog - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.436 ml | 12.182 ml | 24.365 ml |
| 5 mM | 0.487 ml | 2.436 ml | 4.873 ml |
| 10 mM | 0.244 ml | 1.218 ml | 2.436 ml |
| 5 mM | 0.049 ml | 0.244 ml | 0.487 ml |
Last Update：2024-01-02 23:10:35
GLPG634 analog - Introduction
GLPG0634 is a selective small molecule Janus kinase (JAK) inhibitor that regulates immune and inflammatory processes by inhibiting JAK1 and JAK2 activity. It is studied for the treatment of a series of autoimmune diseases, such as rheumatoid arthritis, bone hyperplasia and so on.
About the preparation method, N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl] cyclopropanecarboxa is prepared in the laboratory by synthetic organic chemistry methods. Specific synthetic routes and methods may require reference to relevant research literature or patents.
Last Update：2024-04-09 21:49:45
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Product Name: N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl] cyclopropanecarboxamide Visit Supplier Webpage Request for quotationCAS: 1206101-20-3
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Product Name: N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl] cyclopropanecarboxa Visit Supplier Webpage Request for quotationCAS: 1206101-20-3
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Product Name: N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl] cyclopropanecarboxa Visit Supplier Webpage Request for quotation
CAS: 1206101-20-3
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CAS: 1206101-20-3
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